Over-the-counter anti-aging supplements taken by millions of Americans to boost energy and lessen the side effects of chemotherapy may actually impair cancer treatments, a new study suggests.Researchers at the Case Western Reserve University School of Medicine found that popular vitamin B3 derivatives – including nicotinamide mononucleotide (NMN), nicotinamide riboside (NR) and nicotinamide (NAM) – could help cancer cells survive chemotherapy.Those compounds are used by the body to produce NAD+, a molecule that helps cells generate energy and repair damage.IV THERAPY AND SUPPLEMENTS UNDER SCRUTINY AS EXPERTS WARN OF POTENTIAL SIDE EFFECTSThe study, published in the journal Cancer Letters, examined how these supplements interact with treatments for pancreatic cancer, a particularly deadly form of the disease with a 13% five-year survival rate, according to the American Cancer Society.Over-the-counter vitamin B3 derivatives, specifically NMN, NR and NAM, could help pancreatic cancer cells survive chemotherapy treatment, the study suggests.(iStock)While boosting NAD+ levels through dietary supplements can offer health benefits to non-cancerous cells, pancreatic cancer cells may exploit the extra resources to repair damage caused by chemotherapy and avoid cell death, the researchers found.In both laboratory settings and animal models, the supplements shielded cancer cells against three common chemotherapy drugs: oxaliplatin, 5-fluorouracil and gemcitabine.
As a result, tumors survived chemotherapy doses that typically would prove fatal to them.CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER"Our findings highlight a potentially concerning role for NAD+-boosting supplements in the context of active cancer, especially when used in conjunction with chemotherapy," said study lead Jordan Winter, a professor at Case Western Reserve School of Medicine and co-leader of the developmental therapeutics program at the Case Comprehensive Cancer Center, in the press release.CLICK...