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Widely used diabetes drug may offer unexpected health benefit
For decades, doctors have relied on metformin to help people with type 2 diabetes manage their blood sugar.Now, new research suggests the widely prescribed drug may offer benefits beyond blood sugar control.Researchers at Stanford University found that adults with type 2 diabetes who were taking metformin before catching COVID-19 had a 39% lower risk of dying in the year following their infection than patients taking a different type of diabetes medication.The findings, published in the journal Diabetes, Obesity and Metabolism, point to potential protective effects that go beyond basic glucose control.POPULAR WEIGHT-LOSS DRUGS MAY PREVENT PREDIABETES FROM TURNING INTO DIABETESHigh blood sugar can weaken immune defenses, according to the Centers for Disease Control and Prevention.
Metformin lowers blood sugar and helps the body use insulin more effectively, though it's unclear whether these effects explain the study’s findings.A Stanford-led study of 53,332 U.S.adults with type 2 diabetes found that patients taking metformin before catching COVID-19 had a 39% lower risk of dying over the following year than those taking DPP-4 inhibitors.
(iStock)Researchers noted that the drug may help regulate a biological pathway involved in blood pressure and fluid balance that influences the severity of COVID-19.Earlier studies have also indicated that metformin can reduce inflammation and lower viral levels in the body during an active infection.DIABETES DRUG COULD SLASH RISK OF FATAL HEART CONDITION IN ONE GROUP, SCIENTISTS REVEALTo assess the impact on long-term survival, the team analyzed U.S.
medical records for 53,332 adults with type 2 diabetes who tested positive for COVID-19 between October 2021 and November 2023.All patients were between 30 and 85 years old and had been prescribed either metformin or another diabetes drug, known as dipeptidyl peptidase-4 inhibitor (DPP4i), at least a month before their diagnosis.An independent epidemiologist noted that patients on ...